Glucocorticoids and mineralocorticoids in blood plasma as markers of early diagnostic adrenal cortical tumors

Adrenocortical tumours of the adrenal glands are formed when cells cortical layer grow. The morphological and histological structure benign is variable, which complicates their early diagnosis. study levels hormones in cortex along with analysis symptoms disease will allow not only to differentiate hormone-producing tumours, but also predict direction metabolic processes, make it possible choose right treatment regimen prevent complications from other organs.
 aim determine level cortisol aldosterone assess state pituitary-adrenal renin-aldosterone systems patients various types adrenocortical adenomas.
 Materials methods. hormonal status was assessed by determining glucocorticoids - mineralocorticoids using a direct quantitative enzyme immunoassay. adrenocorticotropic hormone (ACTH) renin determined immunochemical methods monoclonal antibodies specific for ACTH renin.
 Research results. An increase detected against background decrease cortisol-producing adenomas. It shown that aldosteronism we discovered aldosterone-producing adenomas develops an unchanged aldosterone/renin ratio.
 Conclusions. development hormone-dependent accompanied imbalance work systems, changes can serve as criterion diagnosis